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pentobarbital will lessen the level or impact of sunitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Keep track of Closely (1)pentobarbital will reduce the extent or effect of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Loss of, or reduced reaction to tofacitinib may